We discuss a microscopic approach for studying nuclear matter and finite nuclei through the use of realistic nuclear forces derived within the framework of chiral effective field theory. Emphasis will be given to the importance of the leading-order chiral three-nucleon interactions and how their implementation in nuclear many-body calculations may be facilitated by employing alternatively density-dependent two-nucleon forces. Applications to finite nuclei include the description of the anomalously-long beta-decay lifetime of carbon-14 and the construction of microscopic nuclear energy density functionals. We then turn to a description of infinite nuclear matter which we study within the framework of Landau's theory of normal Fermi liquids.