I will discuss several novel aspects of hadron dynamics, including (a) the
implications of intrinsic heavy quarks for the production of charm near threshold at
JLab-12; (b)  the modification of pQCD factorization theorems due to lensing
corrections from initial- and final-state interactions; and (c) the non-universality
of the anti-shadowing of quark distributions in nuclei.  I will also discuss the
phenomenological implications of two new theory developments: "Light-Front
Holography" - a novel approach to color confinement and the origin of the QCD mass
scale; and the "Principle of Maximum Conformality" - a procedure which
systematically eliminates renormalization scale ambiguities and yields
scheme-independent predictions for pQCD.