Since strange quark contributions to nucleon observables must arise entirely through interactions with the vacuum, their sign and magnitude provide key information regarding the nonperturbative structure of the nucleon. Understanding this structure is a grand challenge for nuclear physics and a central focus of research at Jefferson Lab. At the present time, the dominant uncertainty in the experimental numbers for the strange proton form factors arises from the assumption of good charge symmetry which informs their extraction. In fact, with theoretical predictions of the size of charge symmetry violation (CSV) varying through several orders of magnitude, this uncertainty (along with the remarkable experimental challenges) has halted certain aspects of experimental parity-violating electron scattering programs. In this seminar I will describe the use of dynamical 2 + 1-flavour lattice QCD simulation results for the electromagnetic form factors of the octet baryons, together with effective field theory methods, to determine both the strange and CSV form factors of the nucleon to an unprecedented level of precision. In addition, I will present my vision for my research program which will center around the role of hidden flavours and gluons in both hadron and nuclear structure, as well as the 3D spatial and momentum tomography of the nucleon, from lattice QCD. The calculation of gluon observables in the deuteron will make contact with experiments proposed in a JLab letter of intent, while studies of hidden flavor in nuclei will tie in with the ATHENNA experiment. There has recently been significant technical progress which makes the lattice calculation of GPDs and TMDs, which are a focus of the JLab 12GeV research program, an achievable goal.