While the initial HERMES program will focus on the spin-structure function measurements of the nucleons, there is a rich program of physics experiments to be carried out by the HERMES Collaboration. Because the HERMES detector also has pion identification capability, flavor-tagged structure functions can be measured. Also, the -dependence of the asymmetry will give constraints on the spin-fraction carried by the orbital angular momentum of the quarks. Issues of color transparency in production, which were raised in E665 at Fermilab, will be addressed in the HERMES experiment. The process of hadronization will also be investigated in the nucleon and nuclei. The experiment to measure the asymmetry in production will require a laser-driven H/D target and a RICH detector. In addition, detectors and recoil detectors will be implemented to investigate "back-angle'' tagging of structure functions. It is likely that a gas jet target as well as new target chambers and improved beam polarimetry will be necessary.