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PEM Stereotactic Breast Biopsy

West Virginia University
Raymond R. RayIman, Ph. D.
Judith Schreiman, M. D.
Harry Bishop, M. D
Jefferson Lab
Stan Majewski, Ph. D.
Andrew Weisenberger, Ph. D.
Brian Kross
Randy Wojcik
Vladimir Popov

Some PET radiopharmaceuticals demonstrate good breast tumor targeting capabilities (FDG).

PEM is a possibly more effective method for detecting some suspicious breast lesions compared to mammography.

Method for acquiring biopsy samples from suspicious lesions is needed.

PEM Diagram

The arrangement of a pair of detectors making up the PEM imaging system.

PEM-Biopsy System
  • 3.1 x 3 .1 x 10mm GSO crystal wrapped with Teflon tape (30 x 30 array); 10cm x 10cm FOV
  • 4 x 4 array of Hamamatsu R7600-C8 1" square PSPMTs
  • Multi-wire readout to Camac FERA ADCs
  • Acquisition controlled by Kmax running on a G3 Power Mac
  • Images displayed on Power Mac using IDL software
  • Detectors mounted on Lorad biopsy apparatus
Time Test Imaging Time Test

Images showing the ability to discern smaller lesions depending on acquisition time.

Gelatin Breasts Gelatin Breast Phantom Images

Phantom made from food gelatin and radioactive lesions.

PEM Detectors

Photograph of PEM detectors placed under a patient table. A gelatin breast phantom is positioned between two detectors.

PEM detectors successfully intergrated into a Lorad biopsy system.

PEM system had sufficient capabilities to detect small (5mm diameter) simulated breast lesion.

Stereotactic coordinate algorithm demonstrated very good accuracy and precision in calculating the 3-D positions of point sources.