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ES&H Manual
Chapter 6650 Engineered Nanoparticle Program

This chapter defines Jefferson Lab's engineered nanoparticle (NP) program which is consistent with the requirements of 10 CFR 851 and DOE O 456.1.

The field of nanotechnology is rapidly emerging. Much remains unknown about health and environmental effects.

Jefferson Lab treats engineered NP as suspect carcinogens. This chapter and its appendices (ES&H Manual Chapter 6650 Appendix T1 Minimum Mitigation Requirements for Engineered Nanoparticles and ES&H Manual Chapter 6650 Appendix T2 Emergency Procedure for Engineered Nanoparticles) define the administrative and engineering controls; transportation requirements; waste management; and emergency procedures necessary to manage environment, safety, and health (ES&H) concerns associated with the operations involved in synthesis, characterization, or manipulation of engineered NP.


T1 Minimum Mitigation Requirements
All work involving NP is conducted under an OSP or THA which describes the work and indentifies the hazards and controls which are used to mitigate those hazards. ES&H Manual Chapter 6650 Appendix T1 Minimum Mitigation Requirements for Engineered Nanoparticles is used to establish minimum hazard controls.
T2 Emergency Procedures
ES&H Manual Chapter 6650 Appendix T2 Emergency Procedures for Engineered Nanoparticles outlines the procedures for responding to an exposure to spill of engineered nanoparticles (NP).


Management authority may be delegated at the discretion of the responsible manager.

NP Worker
  • Complete and maintain appropriate training, certification, and medical monitoring including: NP Worker Training (SAF 119) and Respirator Training (SAF 200).
  • Obtain authorization from supervisor prior to conducting work.
  • Ensure personal registration as NP worker with Industrial Hygiene and Occupational Medicine.
  • Maintain/write an Operational Safety Procedure (OSP) or Task Hazard Analysis (THA) applicable to the NP activity.
Supervisors/Subcontracting Officer's Technical Representative (SOTR)/Sponsor
  • Complete and maintain appropriate training: NP Worker Training (SAF 119).
  • Register NP worker (staff and Users) with Industrial Hygiene and Occupational Medicine.
  • Coordinate necessary handling, storage, and disposal with Industrial Hygiene prior to ordering or synthesizing.
  • Review all work control documents for activities involving NP.
Industrial Hygiene
  • Complete and maintain appropriate training: NP Worker Training (SAF 119).
  • Maintain the registry of all NP workers and inform Occupational Medicine of new NP workers.
  • Maintain an inventory of activities involving NP in an accessible electronic format.
  • Conduct exposure assessments for all activities involving NP.
  • Monitor the conditions for use of NP in work areas through routine inspections.
  • Provide NP worker training.
  • Review nanoparticle training annually to determine if updates are required.
  • Conducts annual self-assessments to determine compliance with nanotechnology policies and procedures.
Occupational Medicine
  • In accordance with ES&H Manual Chapter 6800 Appendix T1 Medical Monitoring provides medical monitoring to Jefferson Lab NP workers prior to initial assignment. Minimum requirements include:
    • General physical exam;
    • Pulmonary function test; and
    • General blood work.
  • Contacts User NP workers and informs them of Jefferson Lab's medical monitoring requirements. (Occupational Medicine is not required to provide medical monitoring to User NP workers.)


Document Control:
    TECHNICAL POINT-OF-CONTACT:  Jennifer Williams
    APPROVAL DATE:   04/17/09
    • Revision 0.1 - 06/28/13 - Qualifying Periodic Review - Currently no nanoparticle activity; no changes required per JWilliams.
    • REV. 0.1 - 03/30/11 - Updated to remove reference to Chemical Assistance Team.

This document is controlled as an on-line file. It may be printed but the print copy is not a controlled document. It is the user's responsibility to ensure that the document is the same revision as the current on line file. .